SHI Guo-Ning, CHEN Lan*, SHI Hao-Yun, XIE Yun-Hui, HENG Rui-Lin
2013, 44(1): 88-94.
The simulation and finite element analysis of lactose compaction process were carried out by utilizing modified Drucker-Prager Cap model. The tablet properties were systematically studied under different compaction speeds and friction coefficients. The results showed that the upper punch force hardly changed with the different compaction speed, while the shear stress and shear stress band increased with the increasing of compaction speed. The powder fluidity improved as the friction coefficient was decreasing, and the density distribution became more uniform. The friction force between powder and die increased with the increasing of friction coefficient, which induced the decreasing of powder displacement near die. Through the research of pharmaceutical powder, the tablet property can be predicted and which can provide the theory reference for tablet practical production.
